GENERAL CONSIDERATIONS

Biologic Behaviour

•oral OSA is the 4th most common oral tumor in dogs and accounts for 6%-18% of oral tumors

•OSA is more common in appendicular skeleton with only 25.4% in the axial skeleton

•mandibular OSA accounts for 27% of axial OSA (and < 4% of all OSA cases)

•axial OSA, and mandibular OSA in particular, may have a lower metastatic rate than appendicular OSA

TREATMENT

Surgery

•surgical techniques: mandibulectomy and maxillectomy

Surgery and Radiopharmaceuticals

•samarium has been used following partial maxillectomy and local recurrence with survival times > 21 months

Prognosis

•12-month survival rate 59%

•12-month survival rate with combinations of surgery, radiation therapy, and chemotherapy: 35%-59%

•MST for mandibulectomy is 14-18 months with 12-month survival rate 35%-71%, local recurrence rate 15%-28%, and metastatic rate 28%

•MST for maxillectomy is 4.6-10 months with 12-month survival rate 17%-27% and recurrence rate 33%

•poor prognostic factor: high histologic grade for mandibular OSA treated with mandibulectomy