General Considerations
•infiltrative lipomas are locally aggressive with infiltration of normal muscle and fibrous tissue
•large breed dogs are predisposed with a median body weight 30.5 kg
•sex predisposition: females with a male-to-female ratio of 1:4
•well-differentiated adipocytes without evidence of anaplasia and considered benign
•infiltrative lipomas invade muscle, fascia, nerve, myocardium, joint capsule, and bone
•infiltrative lipomas can cause pressure atrophy of muscles, pain, and interfere with normal movement
•aggressive treatment may be required for local control as recurrence is common
•radiation therapy can be considered for unresectable tumors as decreased blood supply may diminish growth
•prognosis: 36% local tumor recurrence, median DFI 239 days, and 1-year DFI 67%
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INFILTRATIVE LIPOMA
