General Considerations
•malignant tumor of striated muscle
•signalment: young dogs
•biologic behaviour: locally invasive with metastasis to lungs, liver, spleen, kidneys, and adrenal gland
•grape-like appearance has resulted in description of botryoid, particularly in the urinary bladder
•histology: large, pleomorphic elongated tumor cells (= strap cells) with cross-striation in eosinophilic cytoplasm
•poor prognostic factors in humans include metastatic disease and poor response to chemotherapy
•age, location, nodal status, and histologic subtype (i.e., embryonal, botryoid, alveolar or pleomorphic) are not prognostic
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