Open VSSO clinical trials

Outcomes of surgical resection and impact of adjuvant therapy on canine carotid paragangliomas

Lead investigators: Dr. Dan Linden and Dr. Brad Matz

The purpose of this study is to describe the pre-, intra- and post-operative workup, features and complications associated with surgical resection of carotid paragangliomas in dogs.

Please contact Dr. Matz for more details. Click here for the study outline and here for the data collection spreadsheet

Evaluation of tumor factors on outcome in dogs following re-excision of the surgical scar in previously incompletely resected soft tissue sarcomas

Lead investigators: Dr. Brandan W Janssens and Dr. Ashton Story

The purpose of the study is to determine the effect tumor factors have on local recurrence and disease-free interval in dogs that have surgical scar revision following inadequately excised soft tissue sarcoma.  

Aims:

1.     Determine if local recurrence following revision surgery is associated with tumor histologic grade determined at the index surgery

2.     Evaluate if other factors have an impact of local recurrence risk and disease free interval such as original tumor size, revision surgical dose, clinical stage, pattern of tumor invasion on original histology, histologic margin using the residual tumor classification (R0, R1, R2) and evidence of disease found on pathology examination at revision surgery. 

Please contact Dr. Janssens for more details. Click here for the study outline and here for the data collection spreadsheet

THE EFFECTS OF ADJUVANT VS. SOLE THERAPY WITH PALLADIA (TOCERANIB PHOSPHATE) IN CANINE GASTROINTESTINAL STROMAL TUMORS (GIST’S) ON LONG TERM SURVIVAL.

Lead investigator: Judith Bertran

The main purpose of the proposed study is to compare the treatment of GIST’s with surgery alone versus in a microscopic setting treated with a full course of Palladia versus in a gross tumor setting with Palladia to determine if there is a clinical benefit to treating GISTs with Palladia

Aims:

1.To compare the disease progression rates and survival times of 3 treatment groups of Gastrointestinal Stromal Tumors (GISTs)— (1) surgery alone versus (2) surgery followed by Palladia (toceranib phosphate) versus (3) Palladia alone in a gross tumor setting. 

2. To determine prognostic indicators associated with GISTs — previously described indicators of prognosis have not been consistent. These included mitotic index, tumor size, histopathologic subtype, and metastasis however these have not been consistent findings across all studies.

3. To determine GIST associated clinical signs, signalment, and most common locations of tumor. 

Please contact Dr. Bertran for more details. Please click here for the study outline and data collection spreadsheet.

OUTCOMES AND PROGNOSTIC FACTORS ASSOCIATED WITH SURGICAL MANAGEMENT OF PRIMARY INTRAMUSCULAR HEMANGIOSARCOMA IN DOGS: A VETERINARY SOCIETY OF SURGICAL ONCOLOGY RETROSPECTIVE CASE SERIES.

Lead investigators: Dr. Ronan A. Mullins and Dr. Michail Vagias

Objectives of the study:

1)    Describe the clinical outcome (progression free interval [PFI], recurrence rate and metastatic rate, and survival time [ST]) of dogs that underwent surgical excision (with or without adjuvant therapy) of primary intramuscular hemangiosarcoma (IMHSA).

2)    Investigate factors associated with tumor recurrence and development of metastasis.

3)    Investigate prognostic factors for progression free interval (PFI) and survival time (ST).

Please contact for more details. Please click here for the study outline and data collection spreadsheet.

Please contact Dr. Mullins for more details. Please click here for the study outline and data collection spreadsheet.